By Saul Suster
The mediastinum is a digital compartment within the chest hollow space that's the seat of numerous very important organs and constructions that may be taken with a number of pathologic tactics, together with congenital and developmental abnormalities, inflammatory stipulations, and benign and malignant neoplasms. The Atlas of Mediastinal Pathology presents a pictorial survey of the foremost illness tactics that may impact this anatomic compartment, together with congenital and bought cysts, benign hamartomatous methods, inflammatory procedures regarding the mediastinum, and benign and malignant neoplasms. The latter comprises tumors of the thymus (thymoma and thymic carcinoma), neuroendocrine neoplasms, germ cellphone tumors, mesenchymal neoplasms, and hematolymphoid malignancies. using ancillary diagnostic tools is illustrated, the place applicable, supplying information for pathologists in arriving on the right diagnosis.
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Extra resources for Atlas of Mediastinal Pathology
103 Histologic appearance of mucoepidermoid carcinoma of the thymus with cystic degeneration. Notice the cystic space on the right surrounded by lymphoid infiltrates with hyperplastic lymphoid follicles 50 2 Thymic Epithelial Neoplasms Fig. 104 Poorly differentiated, nonkeratinizing (lymphoepitheliomalike) squamous cell carcinoma of the thymus is characterized by irregular islands of tumor cells that often display central, comedo-like foci of necrosis. The tumors can contain a prominent lymphoplasmacytoid stromal component similar to that observed in their nasopharyngeal counterparts, or they can show an extensively fibrotic stroma, such as in the current example Fig.
19 Higher magnification from spindle-cell thymoma with adenoid growth pattern shows large, round to oval tumor cells with abundant cytoplasm admixed with a sprinkling of small lymphocytes. 1 Thymomas Fig. 20 Spindle-cell thymoma can often undergo cystic degenerative changes. In this particular example, the tumor is characterized by multiple small cystic spaces, resulting in a reticular pattern of growth Fig. 21 Spindle-cell thymoma with reticular and microcystic growth patterns. Notice that the cells in the walls of the cysts are small and spindled and there are scattered small lymphocytes admixed with the cells and in the cystic lumina 25 Fig.
88 Atypical thymomas are more often invasive at the time of initial diagnosis than other types of thymoma. Pleural and lung involvement is frequently identified in these tumors. The figure shows invasion through the capsule into perithymic fat Fig. 89 Thymomas showing admixtures between WHO types B1 and B2 and WHO type B3 thymoma are commonly encountered. Transitions can be gradual or abrupt, as in the illustrated case. Atypical thymoma can also give rise to thymic carcinoma; extensive sampling is therefore of importance when examining these tumors 2 Thymic Epithelial Neoplasms Fig.