By Mark LeDoux (Editor)
Using animal versions is a key point of clinical learn in different fields of medication. This e-book vigorously examines the real contributions and alertness of animal types to the certainty of human flow issues and may function an important source for uncomplicated neuroscientists engaged in flow problems examine. educational clinicians, translational researchers and easy scientists are introduced jointly to attach experimental findings made in several animal versions to the scientific beneficial properties, pathophysiology and remedy of human circulation problems. a necessary characteristic of this e-book is an accompanying DVD with videos of human stream problems and their corresponding animal types. The booklet is split into sections on Parkinson disorder, Huntington affliction, dystonia, tremor, paroxysmal circulate problems, ataxia, myoclonus, stressed legs syndrome, drug-induced stream issues, a number of procedure atrophy, revolutionary supranuclear palsy/corticobasal degeneration and spasticity. This e-book serves as a necessary source for either clinicians attracted to the technological know-how being generated with animal types and easy scientists learning the pathogenesis of specific flow issues. * presents a unmarried entire source on animal versions of move issues that educational clinicians, translational researchers, and simple neuroscientists can seek advice from* contains contributions by way of specialist flow sickness clinicians and top-level researchers within the box* contains a DVD containing over one hundred seventy movies of human circulation issues and the corresponding animal versions
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Additional info for Animal Models of Movement Disorders
K. Watase, B. M. T. Y. Zoghbi. 2000. Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Sca1 locus. Hum Mol Genet 9:779–785. E. , D. Schmidt, G. Fredow, D. B. Iturrian. 1989. The sz mutant hamster: a genetic model of epilepsy or of paroxysmal dystonia? Mov Disord 4:219–232. , M. Andersson, C. Winkler, D. Kirik, N. A. Cenci. 2002. Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson’s disease. Eur J Neurosci 15:120–132.
The pharmacokinetic profiles of pharmaceuticals will also vary widely among animals and humans: drug dosing cannot be extrapolated from one species to another simply based on body mass. Finally, as a reminder, many human genes have no orthologs in invertebrate species and, as such, the intracellular milieu in flies and worms may differ from humans in important ways. Scientists should be careful when extrapolating the results of molecular manipulations in invertebrates to human disorders. II. CHOICE OF THE APPROPRIATE ANIMAL MODEL The decision to utilize an animal model should be intimately incorporated with the choice of species.
2002 rat injection of sigma receptor ligands into the red nucleus dystonia Walker et al. 1988 rat partial unilateral 6-OHDA lesion of the SNpc & partial unilateral denervation of the orbicularis oculi muscle blepharospasm Schicatano et al. 1997 cat unilateral injection of serotonin into the facial motor nucleus unilateral blepharospasm, hemifacial spasm LeDoux et al. 1998 monkey electrolytic lesions—medial midbrain tegmentum contraversive torticollis Foltz et al. 1959 monkey lesions of mesencephalic tegmentum ipsiversive torticollis Battista et al.