By Douglas J. Martin BS, Edward G. Randles PhD, Marina Ramirez-Alvarado PhD (auth.), Morie A. Gertz, S. Vincent Rajkumar (eds.)
An up to date reference in this attention-grabbing set of complicated issues, this booklet gains the main accomplished innovations for diagnosing, classifying, imaging, treating, and dealing with amyloidosis in a number of organ structures. priceless to the spectrum of practitioners from citizens to sub-specialists, this publication is a succinct authoritative textual content written via leaders within the box. The authors supply guide on all kinds of amyloidosis - together with fundamental amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With crucial therapy algorithms, Amyloidosis: prognosis and therapy is the gold-standard for all hematologists, oncologists, and internists taking care of sufferers with this disease.
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Extra info for Amyloidosis: Diagnosis and Treatment
Sun JP, Stewart WJ, Yang XS, et al. Differentiation of hypertrophic cardiomyopathy and cardiac amyloidosis from other causes of ventricular wall thickening by two-dimensional strain imaging echocardiography. Am J Cardiol. 2009;103:411–5. 76. Klein AL, Hatle LK, Burstow DJ, et al. Doppler characterization of left ventricular diastolic function in cardiac amyloidosis. J Am Coll Cardiol. 1989;13:1017–26. 77. Abdalla I, Murray RD, Lee JC, Stewart WJ, Tajik AJ, Klein AL. Duration of pulmonary venous atrial reversal flow velocity and mitral inflow a wave: new measure of severity of cardiac amyloidosis.
Amyloid and collagenous fiber deposition was correlated with late enhancement that was shown to be associated with fibrosis due to ischemia of cardiomyocytes by small vessel amyloid deposition . In patients with endomyocardial biopsy-proven cardiac amyloidosis, late gadolinium enhancement shows good sensitivity (80%) and excellent specificity (94%) , being strongly correlated with heart failure severity as assessed by brain natriuretic peptide . Magnetic resonance relaxometry, measuring T1 and T2 relaxation times of the left ventricular myocardium, might improve the diagnostic reliability of this technique , and tissue characterization of the myocardium by T1 quantification predicts survival .
99mTc-aprotinin scintigraphic detection of myocardial amyloidosis: long-term follow-up of 78 patients. Eur J Nucl Med. 2001;28:OS413. 25. Schaadt B, Hendel H, Gimsing P, Jønsson V, Pedersen H, Hesse B. 99mTc-aprotinin scintigraphy in amyloidosis. J Nucl Med. 2003;44:177–83. 26. Han S, Chong V, Murray T, et al. Preliminary experience of 99mTc-aprotinin scintigraphy in amyloidosis. Eur J Haematol. 2007;79:494–500. 27. Kula RW, Engel WK, Line BR. Scanning for soft-tissue amyloid. Lancet 1977;1:92–3.