Alley Farming (The Tropical Agriculturalist) by B.T. Kang, A.N. Atta-Krah, L. Reynolds

By B.T. Kang, A.N. Atta-Krah, L. Reynolds

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Eventually, the enzyme homogentisate 1,2-dioxygenase catalyzes the formation of 4-maleylacetoacetate, which is converted into 4-fumarylacetoacetate by maleylacetoacetate isomerase. Subsequently, 4-fumarylacetoacetate produces fumarate and acetoacetate [4, 5]. 5 Important Biomolecules Synthesized from Amino Acids In addition to providing building blocks for proteins, amino acids are precursors of specialized biomolecules including hormones, nuclotides, coenzymes, cell-wall polymers, porphyrins, neurotransmitters, and pigments.

Penicillin acylase was discovered in 1960, but the enzyme-catalyzed process for 6APA production could not compete in terms of yield and productivity with the chemical Delft cleavage process that was soon established. Improvement in stability by screening and recombinant DNA technology, but mainly by immobilization, allowed the gradual replacement of the Delft process that has been now swept out from the market. β-Lactam antibiotics, mainly penicillin and cephalosporins, represent more than 60% of the total antibiotic market with annual sales estimated in US$15 billion.

Nelson DL and Cox MM (2004) Lehninger Principles of Biochemistry, 4th edn. Freeman. Wu G (2009) Amino acids: Metabolism, functions and nutrition. Amino Acids 37: 1–17. Devlin TM (2006) Textbook of Biochemistry with Clinical Correlations. Wiley. Voet D and Voet JG (2004) Amino acid metabolism. , ch. 26. Wiley. Berg JM, Tymoczko, JL, and Stryer, L (2006) Biochemistry. , pp. 27–34. Freeman. Lixiang CP (2009). Catabolism of nutritionally essential amino acids in developing porcine enterocytes. Amino Acids 37: 143–152.

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