Advances in Human Genetics 15 by Michelle M. Le Beau, Janet D. Rowley (auth.), Harry Harris,

By Michelle M. Le Beau, Janet D. Rowley (auth.), Harry Harris, Kurt Hirschhorn (eds.)

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02). Those patients with secondary ANLL who have deletions of 5q or 7q are particularly important because by analysis of the breakpoints we can determine whether certain segments are consistently lost, and, if so, whether a particular segment or critical region is lost in all patients. By studying the breakpoints in 17· patients with an interstitial deletion of 5q, we have identified the critical region as 5q23-q32 (Fig. 8). The identification of the critical regions is relevant because the genes related to the malignant transformation are likely to be located in these regions.

Only 54% of patients with abnormalities in the nonexposed group (17% of all patients) had any of these changes. Golomb et al. (1982) confirmed these findings and in their series Chapter 1: Chromosomal Abnormalities in Leukemia and Lymphoma 31 of 74 patients with ANLL, 25 of 58 nonexposed patients (43%) had clonal abnormalities, as compared to 12 of 16 (75%) exposed patients. A - 5 or del(5q) was observed in 4 of the 12 (33%) exposed patients and in 4 of the 25 (16%) nonexposed patients. 3%) abnormal exposed patients and in 5 of the 25 (20%) abnormal nonexposed patients.

Observed in patients having the disorders listed. Abbreviations: REFRA. , refractory anemia; eLL, chronic lymphocytic leukemia; MPD,myeloproliferative disorders. DISEASE CHROMOSOME Del(lp32)* ABERRATION Del(lp22)" Trisomy lq' ONCOGENE CHROMOSOME NUMBER (') t III 3 :::r o 'a a. ~ 3 III :::II 3=ii ID c :; :I = !!. a o :::II ~ !!. I3 o 3 :::r (') ... III I.. :::r 44 Michelle M. LeBeau and Janet D. Rowley ulin (Ig) loci have been considered in detail by Leder et al. (1983) and arRushdi et al. (1983), and only a few of their pertinent conclusions will be considered here.

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