Advances in Human Genetics 10 by Winifred M. Watkins (auth.), Harry Harris, Kurt Hirschhorn

By Winifred M. Watkins (auth.), Harry Harris, Kurt Hirschhorn (eds.)

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5). , 1975). On the basis of their reaction in quantitative precipitation assays with various purified blood group substances from human ovarian cysts, anti-I sera were classified into six groups and anti-i sera into four groups (Feizi and Kabat, 1972). , 197Ib). The presence of this sequence was recently demonstrated in 1 blood group active poly(glycosyl) ceramides (Zdebska and Koscielak, 1978) and a second anti-l serum (Woj) was shown to be specific for this structure. , 1978). 3GlcNAc(l~3)Gal was inactive.

More recently. net conversion of H-active glycoprotein into a B-active glycoprotein which inhibited the hemagglutination of B cells by anti-B serum, was obtained with a highly purified B transferase isolated from human serum (Carne and Watkins, 1977). The transformation of group 0 red cells into B-active red cells was first demonstrated by Schenkel-Brunner and Tuppy (1970) by means of a B transferase extracted from human gastric mucosal microsomes. A similar conversion was achieved with the enzymes in group B milk (Pacuszka and Koscielek, 1972), group B serum (Race and Watkins 1972a), and group B saliva (Kogure and Furukawa.

A similar conversion was achieved with the enzymes in group B milk (Pacuszka and Koscielek, 1972), group B serum (Race and Watkins 1972a), and group B saliva (Kogure and Furukawa. 1976). The failure of the agalactosyltransferase in human serum to transform cells of the Bombay Oh phenotype was taken as support for the concept that H-active structures are the acceptors of the transferred galactosyl residues (Race and Watkins, 1972a). The activity of the B transferase can be assessed by titration of the converted cells against serial dilutions of anti-B serum.

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